I have it running on Snow Leopard here, but I disabled the built-in install of Apache and am using Zend Server instead.
I know that Mac's installs are quite customized even though lots of the stuff that's included are coming from the open source world. If you're not afraid of the terminal, and config files, I'm pretty sure that you could get Apache to play nice by enabling run-time-loading so that ionCube can run.
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